SAR of 11, 12-Carbamate Macrolides/Ketolides Linked With 1,4- Substituted-[1,2,3]-Triazoles
نویسندگان
چکیده
Structural features associated with ketolide antibiotics that may improve activity over their macrolide predecessors typically include: (1) lack of the 3-O-cladinose (2) presence of 3-keto group (3) the presence of heterocyte tethered to 11, 12-carbamate that interacts specifically with domain II of the bacterial rRNA. A novel compound library was designed to optimize domain II binding and antibacterial activity by the incorporation of the chemically robust [1,2,3]-triazole group.
منابع مشابه
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تاریخ انتشار 2008